RNAIII-inhibiting peptide TFA Fundamentals Explained
TAK-243 preferentially bound to UBA1 more than the relevant E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 decreased levels of ubiquitylated proteins, increased markers of proteotoxic stress and DNA problems stress. In vivo, TAK-243 minimized leukemic load and s